ABSTRACT
The outbreak of the SARS CoV2 ’Coronavirus pandemic’ is believed to have originated in Wuhan in 2019 as a zoonotic spread from bats to humans. It is a highly communicable infection-causing rapid human to human transmission of the virus by virtue of its infectious and pleomorphic nature. The virus has affected millions of people worldwide, with numbers still rising with each passing day. Depleting oxygen saturation levels is amongst the prime concerns in the majority of infected patients. Nasal prongs, face masks, mechanical ventilation and extracorporeal membrane (ECMO) are the commonly used modes of oxygen delivery in such patients. These methods though mostly successful, at times fail to restore the depleting oxygen levels to normal. Hyperbaric oxygen therapy (HBOT) involves the administration of 100% O2 in a special chamber whose pressure is maintained at a level greater than 1 ATP. The main purpose for raising the pressure within the chamber is that as the atmospheric pressure increases, the saturation levels of oxygen in the blood also increase, which eventually result in increased overall tissue oxygenation. This article provides a systematic and wholesome review on the basic principle of hyperbaric oxygen therapy, its effects on the body at a microscopic and macroscopic level, its various uses and its suitability as an adjuvant for the treatment of select COVID-19 infected patients.
ABSTRACT
BACKGROUND: The world is hit by a global pandemic caused by severe acute respiratory syndrome coronavirus, a new genotype of the virus, which causes coronavirus disease, Covid-19. The situation has challenged the entire scientific community nationally as well as internationally to fight back this deadly disease. Since its beginning in November 2019, it has disseminated throughout the human race, regardless of all the measures taken by healthcare sectors, governments, and world health organizations as well. Numerous investigations show that this virus uses air as a passage to commute and spread, the disease most commonly spreads through droplet infections and when comes in contact with the mucous membrane, enters the body. Entire medical staff along with scientists of various nations are working perpetually to develop successful vaccines and drugs to fight back this virus. Amongst various vaccines developing across the world, many of them are in their clinical trials and human trial phases and those which have succeeded in all the trial phases are getting delivered to citizens since December 2020. The present article aims to provide a review of the literature on the type of vaccinations that have been developed so far with their mechanism of action and their basic formulations.
ABSTRACT
The purpose of this study is to focus on how the COVID-19 problem has affected business development. In doing so, it was found the lack of integration between disaster risk management, business, and COVID-19 literature. This research paper focuses on available literature by linking key concepts within the challenges and problems faced by entrepreneurs during the COVID-19 era and have had a profound impact on global economy. A negative impact has been felt on businesses around the world and many newly established businesses and start-ups sent many of their employees on unpaid leaves or laid off which caused job losses and an increasing number in unemployment.